Manchester United have won more league titles than any other club
Fans will line a 4.5-mile route from Manchester Cathedral, in the city centre, to Stretford Mall, Trafford.
A number of roads will be closed to traffic to accommodate the crowds.
Councillor Mike Amesbury, a Manchester United fan, said the city council wanted as many fans and their families as possible to attend.
"Get there nice and early and get a good spot to see your footballing heroes and celebrate the fact we've won 19 league titles.
Alcohol ban "It will be yet another parade on the streets of Manchester."
Greater Manchester Police (GMP) said closures would include Deansgate (from 0700 BST) and Great Ducie Street (from 0900 BST).
Access to many of the roads along the route will also be limited as the parade gets under way at 1000 BST.
Police have also reminded fans that drinking alcohol will not be permitted along the route.
It is the second victory parade in Manchester in a week.
On Monday, up to 100,000 Manchester City fans celebrated their team's first trophy in 35 years with an FA Cup victory parade from Albert Square to the City of Manchester stadium.
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