There may be a sensitive window for developing stress responses
A mother's stress can spread to her baby in the womb and may cause a lasting effect, German researchers propose.
They have seen that a receptor for stress hormones appears to
undergo a biological change in the unborn child if the mother is highly
stressed, for example, because of a violent partner.
And this change may leave the child less able to handle stress themselves.
It has already been linked to mental illness and behavioural problems.
The findings, published in the journal Translational
Psychiatry, are based on a small study of 25 women and their children,
now aged between 10 and 19.
And the researchers point out that the women involved in the
study had exceptional home circumstances and that most pregnant women
would not be exposed to such levels of stress day in and day out.
Furthermore, the researchers say the findings are not
conclusive - many other factors, including the child's social
environment while growing up, might be involved.
But they suspect it is the child's earliest environment, the womb, that is key.
For their study, they looked at the genes of the mums and the adolescents to find any unusual patterns.
Some of the teens had changes to one particular gene - the
glucocorticoid receptor (GR) - that helps regulate the body's hormonal
response to stress.
Such genetic alterations typically happen while the baby is still developing in the womb.
And the scientists believe they are triggered by the mum-to-be's poor state of emotional wellbeing at the time of the pregnancy.
Sensitive window
In the study, these mums had been living with the constant
threat of violence from their husband or partner. And it would appear
this continued stress took its toll on the pregnancy.
When the babies were followed up one to two decades later as
adolescents, they had changes in the genetics of their GR that other
teenagers did not.
This "methylation" of GR appears to make the individual more
tuned in or sensitised to stress, meaning that they will react to it
quicker both mentally and hormonally.
Stress hormones are regulated by the brain's hypothalamus
As people, they tend to be more impulsive and may struggle with
their emotions, explain the researchers, who carried out detailed
interviews with the adolescents.
Professor Thomas Elbert, one of the lead researchers at the
University of Konstanz, said: "It would appear that babies who get
signals from their mum that they are being born into a dangerous world
are faster responders. They have a lower threshold for stress and seem
to be more sensitive to it."
The investigators now plan to carry out more detailed
investigations following larger numbers of mothers and children to see
if they can confirm their suspicions.
Dr Carmine Pariante, an expert in the psychology of stress at
the Institute of Psychiatry, King's College London, said: "This paper
confirms that the early foundation years start at minus nine months."
He added: "Pregnancy is uniquely sensitive to a challenging
maternal psychosocial environment - much more than, for example, after
the baby is born. As we and others have been advocating, addressing
maternal stress and depression in pregnancy is a clinically and
socially, important strategy."
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